你怎么了用英语怎么表达？四种表达

Is that what happened to you?

你就是这样的吗？

What happened to you, darling?

亲爱的，究竟出什么事儿了？

What happened to you, George?

发生了什么事，乔治？

A: I regret for what happened to you.

我对你的事表示遗憾。